Search results for "Alzheimer Disease"
Phase 3 trial shows efficacy of donanemab for Alzheimer disease
In an industry-funded, placebo-controlled trial of patients with early symptomatic Alzheimer disease and amyloid and tau pathology, patients on the investigational drug donanemab showed significant slowing in worsening on the integrated Alzheimer Disease Rating Scale score.
https://immattersacp.org/weekly/archives/2023/07/25/2.htm
25 Jul 2023
MKSAP Quiz: Follow-up evaluation of Alzheimer disease
An 82-year-old woman is seen for follow-up evaluation of Alzheimer disease. Since her last visit 12 weeks ago, she has been taking rivastigmine, with a progressively titrated dosage. The patient's only new symptoms are increasing insomnia, loss of appetite, and occasional diarrhea; she has had no feelings of hopelessness, helplessness, sadness, or guilt. Following a physical exam, Mini–Mental State Examination, and lab tests, what is the most appropriate next step in management?
https://immattersacp.org/weekly/archives/2018/08/07/3.htm
7 Aug 2018
MKSAP Quiz: Impaired gait and balance
A 72-year-old man is evaluated for a 1-year history of progressively impaired gait and balance. He reports that he walks more slowly and is not as agile as he used to be, attributing a recently increased number of falls to not paying enough attention before tripping. In the past 6 months, he has had occasional problems recalling details of recent conversations and events, completing tasks around the house in a timely manner, and organizing and balancing his checkbook despite having been an accountant before retiring. Following a physical exam and MRI of the brain, what is the most appropriate next step in management?
https://immattersacp.org/archives/2017/02/mksap.htm
1 Feb 2017
Biomarkers for Alzheimer's disease may aid diagnosis, predict dementia, studies find
A Swedish study found that blood biomarkers for Alzheimer's disease had high diagnostic accuracy in primary and secondary care, while a U.S. study found that the biomarkers' association with dementia may begin in midlife.
https://immattersacp.org/weekly/archives/2024/07/30/2.htm
30 Jul 2024
MKSAP Quiz: Screening after prostate cancer diagnosis
A 65-year-old man is evaluated after being diagnosed with high-risk prostate cancer. He is asymptomatic. Transrectal ultrasound biopsy showed multiple foci of prostate cancer in both lobes with the highest Gleason score of 8. Following a physical exam, tests, and treatment, what is the most appropriate screening test to perform next?
https://immattersacp.org/weekly/archives/2024/06/25/3.htm
25 Jun 2024
Major shift in thinking about cognitive impairment
Because neurocognitive decline can have a variety of etiologies, a new definition by the DSM-5 defined mild cognitive impairment as a syndrome, and then drilled down to its etiology.
https://immattersacp.org/archives/2019/07/major-shift-in-thinking-about-cognitive-impairment.htm
1 Jul 2019
MKSAP Quiz: Prevent cognitive impairment
A 60-year-old woman comes to the office to discuss the best strategy to prevent cognitive impairment. After a physical exam and cognitive screening testing, what is the most effective preventive measure?
https://immattersacp.org/weekly/archives/2021/11/16/3.htm
16 Nov 2021
Personalized strategies improved cognition, reduced dementia risk in seniors
An intervention with personalized risk-reduction goals, health coaching, and nurse visits was offered to patients who were between the ages of 70 and 89 years and had at least two targeted risk factors for dementia.
https://immattersacp.org/weekly/archives/2023/12/05/2.htm
5 Dec 2023
Alzheimer's markers make management tougher
New guidelines and diagnostic advances are identifying Alzheimer's disease and its precursors much earlier in the course of the disease. The bad news is that, for now at least, these improvements may only create more dilemmas for general internists for the role of biomarkers and communicating with patients.
https://immattersacp.org/archives/2011/09/alzheimers.htm
1 Sep 2011
MKSAP Quiz: A 3-year history of decline in cognition
A 60-year-old man is evaluated for a 3-year history of gradual, progressive decline in his cognition, behavior, and motor skills. Following a physical exam, MRI, and neuropsychological testing, what is the most likely diagnosis?
https://immattersacp.org/weekly/archives/2021/09/28/3.htm
28 Sep 2021